Chemical name:tamoxifen citrate

synonymsnolvadex;tmx;tamoxifene;soltamox;nolvadex(tamoxifen);(z)-[2-[4-(1,2-diphenylbut-1-enyl)phenoxy]ethyl]dimethylammonium dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate;tmx1;txndc;adopan;kessar

cbnumber:cb7853805

molecular formula:c32h37no8

molecular weight:563.64

melting point 140-144 °c

storage temp. 2-8°c

solubility methanol: soluble50mg/ml, clear, colorless

form powder

color white to off-white

water solubility slightly soluble

sensitive light sensitive & hygroscopic

uses

tamoxifen citrate is commonly used in the treatment of women with metastatic carcinoma of the breast to prevent recurrence after surgery or radiation treatment, and as prophylaxis for patients at very high risk to develop breast cancer.

uses

anti-estrogen, protein kinase c inhibitor, beneficial cardiovascular effects, bone cancer treatment, induces dna adduct formation

uses

tamoxifen citrate is a selective estrogen response modifier (serm), protein kinase c inhibitor and anti-angiogenetic factor. tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-oht) and endoxifen by cytochrome p450 isoforms cyp2d6 and cyp3a4.