Cas no.112809-51-5

chemical name:letrozole

synonymsletrozol;femara;letrazole;letrozoleusp28;letrozole(femara);letroz;etrozol;lelrozol;lerozole;laiquzuo

cbnumber:cb9286355

molecular formula:c17h11n5

molecular weight:285.3

melting point 181-183°c

boiling point 563.5±60.0 °c(predicted)

density 1.21±0.1 g/cm3(predicted)

storage temp. 2-8°c

solubility dmso: >50mg/ml

pka 1.52±0.11(predicted)

uses

a nonsteroidal aromatase inhibitor structurally related to fadrozole. antineoplastic

uses

letrozole has been used:

in organoid growth assay to determine its inhibitory capacity(48)

to investigate steroid receptor coactivator-1 (src-1) mediated endogenous estrogen regulation of hippocampal psd-95(49)

to determine its effects on tumor-induced hyperalgesia(50)

for hormonal manipulation in rats(51)

to study its effects on lipocalin-2 (lcn2)(52)

to determine its effects on mechanical hyperalgesia and aromatase expression(53)